Karen is sometimes referred to as a person who is annoying or as an ex-wife who “took custody of the kids”. Now anybody can be a Karen but there are some which many people would agree to be a Karen. There was also a (Hit or miss) parody where they replaced a line with ‘she took the kids.’ There is also a person in the Nintendo switch trailer which could be a Karen based on her looks and someone even made a post about it.
